RT2234 and the Biology of Motor Function in Autism

RT2234 is a first-in-class therapy designed to improve movement, coordination, and physical engagement in autism by targeting key biological drivers—neuroinflammation, oxidative stress, and disrupted neuromuscular signaling.

RT2234 Designed For Autism With Low Muscle Tone

Motor issues like low muscle tone, poor coordination, and physical fatigue are common in autism—but often go unaddressed by current treatments. These symptoms are more than physical. They affect how people move through the world, interact with others, and gain independence.

RT2234 was developed to address this overlooked need. By targeting neuroinflammation, oxidative stress, and neuromuscular signaling, it aims to improve physical control, stamina, and confidence—without sedation or stimulant side effects

RT2234: A Targeted Approach To ASD With Low Muscle Tone

Proposed Mechanism of Action

RT2234 is a novel therapeutic agent designed to modulate the Cholinergic Anti-Inflammatory Pathway (CAP). This innovative compound desensitizes specific receptors without activating them, providing a targeted approach to reducing neuroinflammation while offering cytoprotective and neuroprotective benefits.

  • Reduces neuroinflammation Suppresses inflammatory signals that impair neuromuscular communication and recovery.
  • Combats oxidative stress Restores redox balance to protect muscle cells and nerve terminals from damage linked to fatigue and degeneration.
  • Improves the muscular microenvironment Enhances neuromuscular signaling and cellular energy supply to support tone, contraction, and the conditions needed for muscle repair and resilience.

What Makes RT2234 Different

RT2234 is designed to restore physical strength and coordination in individuals with autism, supporting greater independence and engagement in daily life.

Targeting Shared Biology Beyond Autism

The biological challenges RT2234 addresses—like muscle fatigue, mitochondrial dysfunction, and chronic inflammation—are not limited to autism. They are also central to a range of conditions that affect physical function across the lifespan.

RT2234’s mechanism makes it a strong candidate for treating sarcopenia, frailty, and other forms of neuromuscular decline, especially in aging populations. By improving tone, energy production, and recovery, it may offer a new path forward in conditions where strength and stamina are often overlooked.

Remi Therapeutics: Innovating Today for a Better Tomorrow